Introduction Reprogramming of somatic nuclei into a pluripot

2018-10-20

Introduction Reprogramming of somatic nuclei into a pluripotent state can be achieved through either somatic cell nuclear transfer (SCNT) (Campbell et al., 1996) or ectopic expression of reprogramming factors in somatic cells to generate induced pluripotent stem cells (iPSCs) (Takahashi et al., 200

The numbers of GFAP NSCs did not

2018-10-20

The numbers of GFAP+ NSCs did not return to control levels at even the longest survival times examined (approximately 1 month after AraC and GCV treatment). One possible explanation for this is that we simply did not wait long enough to observe the complete return to control values. Alternatively, t

By studying the relationships of these

2018-10-20

By studying the relationships of these subpopulations to each other, it was found that GMPs are able to create neutrophils but unexpectedly lack the potential to form eosinophils and basophils. Furthermore, and against the prevailing assumption, the GMPs were found to be derivatives of the same bran

By performing selective molecular profiling with LMD we were

2018-10-20

By performing selective molecular profiling with LMD, we were able to demonstrate that the expression of many pre- and postsynaptic molecules, including Bassoon, Piccolo, Synaptophysin, Synapsin, Synaptotagmin, Vglut1, Vglut2, Vgat, Gad65, Gad67, Psd95, Homer1, and Shank1, were observed in the engra

The mechanisms involved in reprogramming somatic cells to

2018-10-20

The mechanisms involved in reprogramming somatic ep4 antagonist to iPSCs by the Yamanaka factors remain poorly understood. Because of the low efficiency and slow kinetics of most reprogramming systems, molecular events that direct somatic cells to pluripotency have been difficult to define. Recent

We have explored the possibility of using the cardiac MSCs

2018-10-20

We have explored the possibility of using the cardiac MSCs of the human fetal heart for expansion of ion channels with characteristics similar to those of mesenchymal progenitors that contribute to mammalian cardiogenesis. In this study cardiac MSCs were reproducibly recovered from the adherent cel

Obviously T changes are not

2018-10-20

Obviously, T2 changes are not specific for certain alterations in ABT-199 current, as modulators with different modes of action (ATX-II, Bay K-8644, E-4031) all result in similar changes. Moreover, relaxation time was also prolonged by EMD-57033, a relatively pure calcium sensitizer that prolongs re

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2018-07-29