• br Materials and Methods br Results br Discussion There

  2018-11-07

  

  Materials and Methods Results Discussion There is an increasing awareness of the central role endothelial dysfunction plays in CV disorders. Low numbers of EPC-CFUs strongly correlate with endothelial dysfunction (Werner et al., 2007) and are associated with a high Framingham risk score for

• The extracellular matrix ECM is important

  2018-11-07

  

  The extracellular matrix (ECM) is important for the integrity of the aortic wall and mutations in ECM genes such as Fibulin-4 and Fibrillin-1 hence lead to aneurysm formation. Genetic studies in Fibulin-4 and Fibrillin-1 mutant mice implicated dysregulation of the TGF-β pathway as an important hallm

• salt inducible kinase Due to the importance of ClfA as a vir

  2018-11-07

  

  Due to the importance of ClfA as a virulence factor, the protein has been explored as a potential vaccine candidate. Recombinant ClfA induced an antibody response in mice (Josefsson et al., 2008) and mice immunized with ClfA presented with less severe arthritis compared to mice immunized with a cont

• In total the selected model explained se and

  2018-11-07

  

  In total, the selected model explained 60% (se=8%) and 98% (se=9%) of the phenotypic variation in MDD and SDD, respectively (Fig. 3). Strikingly, the effect of the shared couple environment contributed as much as 14% (se=7%) and 22% (se=7%) of the phenotypic variance in MDD and SDD respectively. Fo

• br Introduction Von Willebrand factor

  2018-11-07

  

  Introduction Von Willebrand factor (VWF), the largest circulatory glycoprotein, supports shear stress-associated platelet adhesion and aggregation at sites of vascular injury (Moake, 1986; Sadler, 2005). VWF is synthesized by endothelial cells (Jaffe et al., 1974) and megakaryocytes (Sporn et al.

• br Funding The work was financially supported by

  2018-11-07

  

  Funding The work was financially supported by the by grants from the Ministry of Science and Technology of the People\'s Republic of China (2014AA020524), the Special Research Fund of Ministry of Health for Non-Profit Sector (201302010), the National Nature Science Foundation (81302507), the Scie

• A successful vaccine should lead

  2018-11-07

  

  A successful vaccine should lead to the generation of long-lived plasma cells and memory B cells that are thought to be essential for sustained humoral immunity. However, during chronic infection, the persistence of viral glutathione s-transferase alters B cell differentiation into memory cells (Co

• br Conclusions Outstanding Questions and

  2018-11-07

  

  Conclusions, Outstanding Questions, and Future Directions To resolve these and other questions future directions must include synergistic collaborative efforts focused on aligning insights from human and laboratory aging studies. Development of advanced computational approaches such as meta-analy

• These last few years have seen a shift in emphasis

  2018-11-07

  

  These last few years have seen a shift in emphasis from the investigation of individual age-related diseases in isolation toward a broader context to define the basic biology of aging. The concept behind the recently coined pursuit of GeroScience (Burch et al., 2014) is that a strategy to delay the

• Similarly for most tissue and cell types where

  2018-11-07

  

  Similarly, for most tissue and cell types where NFIB is expressed, only a few direct downstream targets have been identified. Examples include EZH2, which is repressed by NFIB during cortical development (Piper et al., 2014) but activated by NFIB in melanoma (Fane et al., 2017), IGFBP5 which is acti

• br Experimental design Tumor tissue samples from retinoblast

  2018-11-07

  

  Experimental design Tumor tissue samples from 8 retinoblastoma patients and from 5 medulloblastoma patients were collected. These 13 samples were deep sequenced as three pools, two for retinoblastoma and one for medulloblastoma. The in silico references were generated from a whole human cantharid

• eukaryotic initiation factor br Experimental design material

  2018-11-07

  

  2. Experimental design, materials and methods The experiment was conducted at a rice field with long and short duration variety of BPT5204 (150 days) and IR64 (90–120 days), which normally yields 5.5 to 6.5t/ha-1 and 4.0 to 4.5t/ha-1 in 2013–2014 at rice field of Alapakkam: Latitude: 11.3600°N an

• br Discussion This study provides a pipeline

  2018-11-07

  

  Discussion This study provides a pipeline to structure 16S rRNA gene sequence information constructing digitalized datasets on Lysinibacillus strains currently present in several culture collections (GSBTM Gujarat, NCMR-NCCS Pune and NCIM-NCL Pune) in India and many other National Culture Collect

• Our review proceeds in the following sections First we

  2018-11-07

  

  Our review proceeds in the following sections. First, we discuss neurobiological susceptibility models (Ellis et al., 2011). While not traditionally centered on direct assessments of the brain, they have guided work on how endogenous, biological factors, such as genotype, render some individuals rel

• Taken together studies of both neuroanatomy and neural

  2018-11-07

  

  Taken together, studies of both neuroanatomy and neural functional activation yield SES-related differences in purchase GSK126 regions that support language; these findings, however, have not reliably been linked to differences in language functioning. Importantly, a recent study has shown no measu

16362 records 1073/1091 page Previous Next First page 上5页 10711072107310741075 下5页 Last page