• br Results and Discussion br Conclusion What we have shown

  2019-08-02

  

  Results and Discussion Conclusion What we have shown here is that highly specific antagonist can be a very useful tool, can mimic gene KO experiments or even further dissect receptor function. We just took ETA antagonist as an example and found that ETA mediates physiological closure of DA whi

• br The modulation of ER

  2019-08-02

  

  The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective death associated protein kinase receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with

• br Conclusion Our study demonstrates that the effects

  2019-08-02

  

  Conclusion Our study demonstrates that the effects of Epac activation are strongly conditioned by the steady-state Ca levels at which the myocyte is functioning. As intracellular Ca increases, the activity of CaMKII enhances and the phosphorylation of its SR substrates acquires different relevanc

• To compare the phage of

  2019-08-02

  

  To compare the phage of the 4th round results, we conducted isolated single rounds of FGE screening as described above for the 4 individual phage 4(1), 4(2), 4(3), and NC then determined the number of colony forming units afforded by cleavage from the support. Interestingly, we found that the 4(2) s

• Enolases are among the most abundantly expressed cytosolic p

  2019-08-02

  

  Enolases are among the most abundantly expressed cytosolic proteins. They are metalloenzymes that catalyze the conversion of 2-phosphoglycerate to phosphoenolpyruvate [18]. Eubacteria and archaebacteria have a single enolase gene (reviewed in [19]). Despite the lack of signal peptides or cognate pro

• In regards to regional variation in metabolic

  2019-08-02

  

  In regards to regional variation in metabolic behavior of adipose tissue, subcutaneous adipose tissue transplantation has been shown to reprogram visceral adipose tissue to have subcutaneous-like phenotypic behavior, whereas visceral-to-subcutaneous transplantation does not promote a more detrimenta

• HCV has evolved mechanisms to evade humoral immune responses

  2019-08-02

  

  HCV has evolved mechanisms to evade humoral immune responses including high functional flexibility and variability of immunogenic portions of its envelope proteins. The highest sequence variability occurs in the first 27 ionophores of the N-terminus of E2, which is referred to as the hypervariable r

• br NADH and NADPH Turnover and the

  2019-08-02

  

  NADH and NADPH Turnover and the Putative Role of Alternative NAD(P)H Dehydrogenases Still very little is known about the metabolic function of external and internal alternative NADH:UQ oxidoreductases, and almost nothing is known about the mechanisms underlying their metabolic regulation, especia

• br Materials and methods br Results

  2019-08-01

  

  Materials and methods Results Discussion Schistosome cercarial elastase secreted from the acetabular glands of cercariae is recognized to play a critical role in mammalian host skin penetration upon infection. The present study extends the understanding of biochemical and immunological prop

• br The related catalytic regions of the human

  2019-08-01

  

  The related catalytic regions of the human DNA ligases contain three domains, a DNA binding domain (DBD), a nucleotidyl transferase domain (NTase) and an oligonucleotide/oligosaccharide-fold binding domain (OBD) (Ellenberger and Tomkinson, 2008). Similar to DNA ligase I, the DNA ligase III polypep

• br Materials and methods br

  2019-08-01

  

  Materials and methods Results Discussion In this paper, we have demonstrated application of the glmS ribozyme reverse genetic tool for chemogenomic profiling in Plasmodium spp. This tool can provide robust attenuation of expression for different target genes, across different strains varyin

• Classical DHFR inhibitors such as methotrexate

  2019-08-01

  

  Classical DHFR inhibitors such as methotrexate (MTX) bind tightly to the enzyme and possess adequate clinical pharmacokinetics. MTX bind to the DHFR binding site through the formation of hydrogen bonds with Asn64, Lys68, Arg28, Arg70, Val115 and Ile7 amino Amikacin residues as well as hydrophobic i

• High throughput screening HTS of the AstraZeneca compound

  2019-08-01

  

  High throughput screening (HTS) of the AstraZeneca U 73343 solubility collection was conducted and identified oxadiazole amide () originating from a kinase directed screening library (although inactive against a panel of kinases). This compound had moderate potency as a DGAT-1 inhibitor (IC=0.52μM

• KSTDs are generally reported to

  2019-08-01

  

  — Δ1-KSTDs are generally reported to be intracellular enzymes, either soluble or bound to subcellular particles. For instance, the enzymes from C. testosteroni ATCC 11996 and ATCC 17410 [50,90,99], R. equi [29], and N. simplex ATCC 6946 [52] were particulate-bound. On the other hand, the Δ1-KSTDs f

• Our western blotting results showed

  2019-08-01

  

  Our western blotting results showed that phospho-DDR1 levels continued to increase after I/R injury, and the overall activation trend between phospho-DDR1 and MMP-9 was the same. We found that phospho-DDR1 expression started to increase significantly at 12h after I/R injury, which may be related to

15544 records 957/1037 page Previous Next First page 上5页 956957958959960 下5页 Last page