• RPE monolayers grown on cell carriers

  2018-11-08

  

  RPE monolayers grown on cell carriers would facilitate surgical handling and long-term functionality by substituting some or all of the functions of the aged Bruch’s membrane (Binder et al., 2007). Coimplantation of differentiated RPE monolayers on a substrate has been attempted in animal models onl

• JNK signaling promotes the expression of cytoprotective gene

  2018-11-08

  

  JNK signaling promotes the expression of cytoprotective genes in flies, which contributes to tissue homeostasis loss in aged guts (Biteau et al., 2008). We found that JNK activity was increased in dbr- and ptc-depleted guts, and further inhibition of JNK activity in these guts effectively suppressed

• Brefeldin A manufacturer br Materials and methods br Results

  2018-11-08

  

  Materials and methods Results Discussion In this study we demonstrated that DPSCs may be induced to a greater differentiation into osteoblasts by selective stimulation of A1R. We started our study based on the known capability of DPSC to differentiate into osteoblasts (Huang et al., 2009;

• Understanding of potential mechanisms involved

  2018-11-08

  

  Understanding of potential mechanisms involved in the initial inherent neuronal bias of cultures and then using small molecules to alter this bias towards astrocyte lineages will enable uniform and faster processes to generate astrocytes. Here we explore the epigenetic mechanism that maintains the p

• Our previous study Ara et al demonstrated the protective eff

  2018-11-08

  

  Our previous study (Ara et al., 2011) demonstrated the protective efficacy of hypoxic-preconditioning against hypoxic–ischemic injury in newborn piglet model. We showed that hypoxic exposure for 3h, 24h before hypoxia–ischemia, was effective in reducing glutathione s-transferase damage in newborn p

• br Materials and methods br

  2018-11-08

  

  Materials and methods Resource table. Resource details Fanconi anemia (FA) is caused by genetic defects in the Fanconi anemia pathway (FA-pathway), which is involved in DNA inter-strand cross-link repair. The disease is characterized by progressive bone marrow failure with a significant num

• br Introduction Foundational cell fate reprogramming

  2018-11-08

  

  Introduction Foundational cell fate reprogramming studies revealed ectopic expression of pluripotency-associated transcription factors (TF) OCT4, SOX2, KLF4, and c-MYC (OSKM) or OCT4, SOX2, NANOG, LIN28 (OSNL) in human fibroblasts (hFibs) cultured in pluripotent supportive conditions was sufficie

• Pluripotent stem cell marker analysis iPSCOCT express plurip

  2018-11-08

  

  Pluripotent stem cell marker analysis: iPSCOCT4 express pluripotent markers SSEA3, TRA-1-60, OCT4, NANOG and SOX2 as measured by flow cytometry (Fig. 1E). Pluripotent functionality: iPSCOCT4 are capable of three germ layer differentiation capacity as assessed by in vivo teratoma assay (Fig. 1F).

• In the current study we compared two different genetic backg

  2018-11-08

  

  In the current study, we compared two different genetic backgrounds on the induction and maintenance of multipotency by generating clonal iNSC lines from two distinct mouse strains (C57BL/6 vs. C3H). Clonal iNSC lines from distinct genetic backgrounds exhibited the distinct levels of conversion effi

• br Author contributions br Conflict of interests br Acknowle

  2018-11-08

  

  Author contributions Conflict of interests Acknowledgments We thank Dr. Wenying Liu for her help with the initial setup of the electrospinning and Mr. Xiyu Li for his assistance with SEM. We also thank Emory Children\'s Pediatric Research Center Flow Cytometry Core and Animal Physiology Cor

• Recently human umbilical cord hUC has been investigated

  2018-11-08

  

  Recently, human umbilical cord (hUC) has been investigated as a source of pten inhibitor with stem/progenitor cell properties. hUC is a desirable source of stem/progenitor cells as it is routinely discarded after delivery, collection is non-invasive and an abundant number of cells are present in cor

• P and p are cyclin dependent kinase inhibitors that play

  2018-11-08

  

  P21 and p16 are cyclin-dependent kinase inhibitors that play important roles in cell-cycle regulation and tumor suppression (Poole et al., 2004; Shapiro et al., 1998), and both are highly expressed upon senescence in MSCs. Knockdown of p21 in late-passage MSCs increases stem cell properties, includi

• br Materials and methods br Results

  2018-11-08

  

  Materials and methods Results Discussion NPY is one of the most common neuropeptides in mammals, and it is abundant in the central and peripheral nervous system. Recent studies have indicated that the neuropeptides SP and NPY can regulate many biological activities in BMSCs and MC3T3 Wnt ag

• Most remarkably we identified Nppb Bnp a well

  2018-11-08

  

  Most remarkably, we identified Nppb (Bnp), a well-studied marker in cardiovascular disease, as a novel putative Shox2 target gene. This gene was analyzed as working myocard marker and turned out to be significantly upregulated in Shox2 SAN-like Batimastat and in right atrial tissue of Shox2-KO embr

• br Experimental Procedures br Acknowledgments br Introductio

  2018-11-08

  

  Experimental Procedures Acknowledgments Introduction Germ Y27632 are the only cells that continue to be reprogrammed throughout their lifetime in order to transfer genetic information to subsequent generations (Sasaki and Matsui, 2008). Germ cells have unique characteristics such as genome-

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