• br Materials and methods br Results

  2018-10-20

  

  Materials and methods Results Discussion riPSCs are typically generated and cultured on MEF feeders (Liu et al., 2008). Feeders are sufficient to support rhesus iPSC long-term maintenance. However, this approach is too labor intensive for large-scale culture. Optimization of this culture sy

• br Materials and methods br Results br

  2018-10-20

  

  Materials and methods Results Discussion Obesity results when caloric intake exceeds energy expenditure, with an increase in adipocyte size or adipocyte number (Bjorntorp, 1974; Faust et al., 1978; Johnson et al., 1971, 1978; Yu et al., 1997). In the context of adipogenesis, development app

• In this study we demonstrated that unrelated

  2018-10-20

  

  In this study, we demonstrated that unrelated allogeneic human MSCs supported a LSC phenotype in a largely quiescent state in a long-term vitro culture system. We then confirmed the persistence of LIC after 6weeks co-culture with MSCs using the NSG mouse xenotransplant model. Our results also reveal

• br Source of funding This work was

  2018-10-20

  

  Source of funding This work was supported by research funding from The Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research (C) (22591555) and the Riken Center for Developmental Biology Collaborative Research Fund, Kobe (08001475). Disclosures

• Currently because of the lack

  2018-10-20

  

  Currently, because of the lack of biomarkers that identify DSCs specifically, the only way to monitor relative changes in their number and quality is by functional assays. In animal model research, changes in DSCs are monitored by the ability of transplanted donor corticotropin releasing factor to

• UV induced changes in the cornea are largely mediated

  2018-10-20

  

  UV-induced changes in the cornea are largely mediated by the up-regulation of pro-inflammatory cytokines such as interleukin (IL)1 (Corsini et al., 1997), IL6 (Di Girolamo et al., 2002), IL8 (Di Girolamo et al., 2002) and tumour necrosis factor alpha (TNFα) (Kennedy et al., 1997) which correlate to

• Following from our prior research

  2018-10-20

  

  Following from our prior research to derive new hESC lines under increasingly defined culture conditions (Fletcher et al., 2006) we sought to establish a facility within which our experience and evolving practice and reagents could be implemented to a GMP and professionally accredited standard. Here

• br Materials and methods br Results br Discussion The role

  2018-10-20

  

  Materials and methods Results Discussion The role played by Nurr1 in the regulation of NPCs across several beta lactamase inhibitor regions has been extensively investigated. It has been suggested that Nurr1 may exert a strong control on both the proliferation and differentiation of NPCs in

• Introduction Reprogramming of somatic nuclei into a pluripot

  2018-10-20

  

  Introduction Reprogramming of somatic nuclei into a pluripotent state can be achieved through either somatic cell nuclear transfer (SCNT) (Campbell et al., 1996) or ectopic expression of reprogramming factors in somatic cells to generate induced pluripotent stem cells (iPSCs) (Takahashi et al., 200

• The numbers of GFAP NSCs did not

  2018-10-20

  

  The numbers of GFAP+ NSCs did not return to control levels at even the longest survival times examined (approximately 1 month after AraC and GCV treatment). One possible explanation for this is that we simply did not wait long enough to observe the complete return to control values. Alternatively, t

• By studying the relationships of these

  2018-10-20

  

  By studying the relationships of these subpopulations to each other, it was found that GMPs are able to create neutrophils but unexpectedly lack the potential to form eosinophils and basophils. Furthermore, and against the prevailing assumption, the GMPs were found to be derivatives of the same bran

• By performing selective molecular profiling with LMD we were

  2018-10-20

  

  By performing selective molecular profiling with LMD, we were able to demonstrate that the expression of many pre- and postsynaptic molecules, including Bassoon, Piccolo, Synaptophysin, Synapsin, Synaptotagmin, Vglut1, Vglut2, Vgat, Gad65, Gad67, Psd95, Homer1, and Shank1, were observed in the engra

• The mechanisms involved in reprogramming somatic cells to

  2018-10-20

  

  The mechanisms involved in reprogramming somatic ep4 antagonist to iPSCs by the Yamanaka factors remain poorly understood. Because of the low efficiency and slow kinetics of most reprogramming systems, molecular events that direct somatic cells to pluripotency have been difficult to define. Recent

• We have explored the possibility of using the cardiac MSCs

  2018-10-20

  

  We have explored the possibility of using the cardiac MSCs of the human fetal heart for expansion of ion channels with characteristics similar to those of mesenchymal progenitors that contribute to mammalian cardiogenesis. In this study cardiac MSCs were reproducibly recovered from the adherent cel

• Obviously T changes are not

  2018-10-20

  

  Obviously, T2 changes are not specific for certain alterations in ABT-199 current, as modulators with different modes of action (ATX-II, Bay K-8644, E-4031) all result in similar changes. Moreover, relaxation time was also prolonged by EMD-57033, a relatively pure calcium sensitizer that prolongs re

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