• FPET is a valuable tool

  2019-05-13

  

  FPET is a valuable tool to support monitoring of SDG 3·7, which calls for universal access to family planning by 2030, albeit with a focus on demand and utilisation rather than access. Nonetheless, subnational geographic projections must be considered in light of some data limitations. Unmarried wo

• br Introduction Since Reekers and Bolia introduced subintima

  2019-05-13

  

  Introduction Since Reekers and Bolia introduced subintimal angioplasty, the trans-subintimal route has become the preferred technique to advance the guidewire through a totally occluded and often heavily calcified lesion, especially in the aortoiliac segment. The technical failure was seen in 20–

• br Conclusion br Conflict of interest

  2019-05-13

  

  Conclusion Conflict of interest Introduction The implantable cardioverter-defibrillator (ICD) has dramatically reduced the risk of sudden death in patients with malignant ventricular tachyarrhythmias [1,2]. However, 10–30% of patients who have undergone ICD implantation experience “electric

• In the present study we found that stathmin was significantl

  2019-05-13

  

  In the present study, we found that stathmin was significantly down-regulated upon treatment with a combination of Zol and gefitinib. The down-regulation of stathmin, which was not detected by 2-D DIGE after treatment with either agent alone, was considered to be attributable to cooperative effect o

• br Conclusion br Conflict of interest

  2019-05-13

  

  Conclusion Conflict of interest statement Authors\' contribution Introduction There are two classes of bisphosphonates that differ with regard to structure and mechanism of action [1]. The first one includes pyrophosphate-resembling bisphosphonates, such as clodronate and etidronate, wh

• pkc inhibitors br Discussion Wellens reported an association

  2019-05-13

  

  Discussion Wellens [1] reported an association between accessory pathways characterized by anterograde decremental conduction and the description of nodoventricular connections by Mahaim [2]. Consequently, these accessory pathways were erroneously referred to as “Mahaim pathways.” McClelland et a

• NCS is a rare syndrome In case

  2019-05-13

  

  NCS is a rare syndrome. In case series of NCS 14–47% were associated with of lymphoproliferative disorders [reviewed in [12]]. Survival is usually dictated by the underlying disease and short in the setting of aggressive malignancies. Since NCS may be a manifestation of an underlying malignancy it h

• The importance of social determinants on population health i

  2019-05-13

  

  The importance of social determinants on population health is widely known. Beyond this recognition, key questions that still need to be addressed include research into how to best address social determinants through intersectoral collaboration. Pillay-van Wyk and colleagues identify this approach a

• LJI308 cost A critical link exists between awareness of risk

  2019-05-13

  

  A critical link exists between awareness of risk, the presence of disease, and steps taken by the patient and clinician to change the natural history of disease. Chronic illnesses such as diabetes mellitus, dyslipidaemia, anaemia and a multitude of endocrinological and rheumatological diseases are r

• br Genetic basis Similar to other arrhythmia syndromes

  2019-05-10

  

  Genetic basis Similar to other arrhythmia syndromes, Brugada and early repolarization syndromes are inherited diseases that are usually transmitted in an autosomal-dominant manner [26]. To date, 13 genes have been associated with Brugada syndrome. Loss-of-function mutations in SCN5A, encoding the

• The incidences of AF and AT have

  2019-05-10

  

  The incidences of AF and AT have been shown to be relatively high after minimally invasive AF surgery [18–20]. Edgerton et al. [18] demonstrated that checkpoint activation freedom from AF or AT should be assessed by long-term monitoring. Kron et al. [19] showed that 40% of patients could undergo bi

• Our findings show that primary

  2019-05-10

  

  Our findings show that primary prevention ICD recipients experienced an impaired QOL on vitality subscales, which were included in the physical health domain, compared to secondary prevention ICD recipients. Similarly, Berg et al. also found that ICD patients with a primary prevention indication had

• Nademanee et al reported nine symptomatic patients with BrS

  2019-05-10

  

  Nademanee et al. reported nine symptomatic patients with BrS who experienced VF and underwent electrophysiological study and catheter ablation [8]. The patients exhibited abnormal epicardial electrograms characterized by fragmented electrograms with a relatively low voltage ( Idiopathic ventricular

• Performing an ajmaline test in children is problematic

  2019-05-10

  

  Performing an ajmaline test in children is problematic for 2 reasons. First, the test is apparently less sensitive in children than in adults. In fact, in 1 study, a repeat ajmaline challenge performed after puberty unmasked BrS in 23% of relatives with a previously negative drug test performed duri

• br Primary biliary cholangitis Primary biliary

  2019-05-10

  

  Primary biliary cholangitis Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is another rare but devastating immune-mediated cholangiopathy. Similar to PSC, PBC is characterized by portal inflammation leading to fibrosis and eventually cirrhosis. Distinct from PSC

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